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Melatonin Release Cascade

Meaning

The Melatonin Release Cascade is the specific, multi-step neuroendocrine pathway responsible for the rhythmic synthesis and secretion of the hormone melatonin from the pineal gland, which is the primary signal for darkness and the regulator of the sleep-wake cycle. This cascade is initiated by environmental light cues and is essential for synchronizing the body’s internal circadian rhythm with the external 24-hour cycle. A properly functioning cascade is fundamental for restorative sleep and the subsequent nocturnal repair processes. Disruption of this cascade impairs circadian function.