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Melatonin Recalibration

Meaning

The clinical process of intentionally restoring the proper timing, amplitude, and duration of the nocturnal melatonin secretion curve to re-establish a healthy sleep-wake cycle and circadian rhythm. Melatonin, a key chronobiotic hormone secreted by the pineal gland, is essential for signaling darkness to the body’s master clock and initiating the cascade of sleep-related physiological processes. Recalibration is necessary when modern light exposure or lifestyle habits have suppressed or shifted this critical nocturnal signal.