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Melatonin Precursor Synthesis

Meaning

Melatonin Precursor Synthesis refers to the sequential, enzymatic conversion pathway within the pineal gland and other tissues that transforms the essential amino acid L-Tryptophan into the crucial sleep-regulating hormone, melatonin. This biosynthetic process involves two key intermediate steps: the conversion of Tryptophan to 5-hydroxytryptophan (5-HTP) and then to the neurotransmitter Serotonin, followed by the final two-step conversion to N-acetylserotonin and ultimately Melatonin. The availability of the precursor and the activity of the rate-limiting enzymes are vital for robust nocturnal melatonin production.