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Melatonin Initiation

Meaning

Melatonin Initiation refers to the precise biological event marking the beginning of the nocturnal rise in melatonin secretion from the pineal gland, a point often clinically measured as the Dim Light Melatonin Onset (DLMO). This specific surge is recognized as the body’s primary systemic signal for darkness and the commencement of the biological night. Clinically, a significantly delayed or pathologically blunted initiation is a key indicator of underlying circadian rhythm disruption, frequently associated with sleep onset insomnia or chronic phase delay disorders. Optimizing the exact timing of this initiation is crucial for synchronizing the entire sleep-wake cycle and promoting deep, restorative sleep.