What is the Origin of Melatonin Impact Glucose?

This term stems from the intersection of endocrinology and chronobiology, highlighting the direct metabolic role of the sleep-regulating hormone melatonin. Impact refers to the measurable influence on glucose homeostasis. Glucose is the body's primary circulating sugar.

What is the Mechanism of Melatonin Impact Glucose?

Melatonin acts on specific receptors found in pancreatic beta-cells and peripheral metabolic tissues, which transiently impairs insulin secretion and reduces the sensitivity of target cells to insulin. This results in a state of nocturnal insulin resistance, a natural defense mechanism. Consuming carbohydrates late in the evening, when melatonin levels are high, exacerbates this physiological resistance, leading to higher and more prolonged postprandial glucose excursions compared to the same meal consumed earlier in the day.

Melatonin Impact Glucose ∞ Area

Melatonin Impact Glucose

Meaning

The physiological effect of the pineal gland hormone melatonin on glucose metabolism and insulin sensitivity, particularly during the nocturnal rest phase. Melatonin’s presence, which signals biological night, is associated with a temporary, physiological reduction in glucose tolerance, a mechanism intended to conserve energy and glucose for the brain during sleep. Understanding this impact is vital for managing late-night carbohydrate intake.