What is the Origin of Melanotan II Tanning Peptide?

The peptide was originally developed and studied in the late 1980s at the University of Arizona for its potential as a photoprotective agent to help prevent skin cancer. Its name is a combination of "Melano-" referring to melanin and "tan" describing its primary visible effect on skin pigmentation.

What is the Mechanism of Melanotan II Tanning Peptide?

Melanotan II binds selectively to melanocortin receptors, especially the MC1 receptor found on melanocytes, triggering an intracellular signaling cascade involving adenylyl cyclase and protein kinase A (PKA). This cascade ultimately stimulates the production and dispersion of the dark melanin pigment within the skin, providing a darker complexion and potential photoprotection.

Melanotan II Tanning Peptide ∞ Area

Melanotan II Tanning Peptide

Meaning

A synthetic analog of the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH) that is clinically utilized to induce melanogenesis, resulting in skin darkening or tanning without extensive sun exposure. This peptide acts as a potent agonist at certain melanocortin receptors, primarily MC1R, offering a method to increase melanin production. It is noted for its potential to alter pigmentation and its off-target effects on appetite and sexual function.