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Melanocortin Receptor Activation

Meaning

Melanocortin Receptor Activation is the specific biochemical process where melanocortin peptides bind to and stimulate a family of G-protein coupled receptors (MC1R through MC5R) located on various cell types throughout the body. This activation initiates a downstream signaling cascade that regulates a diverse range of physiological functions, including pigmentation, energy homeostasis, sexual function, and inflammation. In the hormonal and metabolic domain, MC4R activation in the hypothalamus is a critical pathway for regulating appetite and energy expenditure. Targeted therapeutic strategies often seek to modulate this activation to address conditions like obesity or sexual dysfunction.