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Medication Interactions

Meaning

A clinical event where the effects of one medication or bioactive compound are altered by the concurrent administration of another substance, leading to an increase or decrease in therapeutic efficacy or the risk of adverse reactions. In hormonal health, this is particularly relevant due to the hepatic metabolism of many endocrine agents and supplements via the Cytochrome P450 enzyme system. Careful clinical review of all concomitant substances is mandatory to ensure patient safety.