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Medication Interaction Risk

Meaning

Medication interaction risk refers to the potential for two or more concurrently administered drugs, or a drug and a food/supplement, to alter the pharmacological effects of one another, leading to an unpredictable change in efficacy or toxicity. This clinical concern arises when the combination results in an unintended potentiation, inhibition, or entirely new adverse effect. Careful clinical review and pharmacovigilance are necessary to mitigate these risks, particularly for patients on chronic hormonal replacement or complex polypharmacy regimens. Understanding the metabolic pathways involved is key to preventing harmful outcomes.