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Mechanistic Plausibility

Meaning

Mechanistic Plausibility refers to the biological and scientific credibility of a proposed causal link or mechanism of action between an intervention and a clinical outcome. In clinical science, this principle is used to evaluate the likelihood that an observed therapeutic effect is genuine, even when direct clinical trial data may be limited or inconclusive. It requires a clear, step-by-step articulation of the physiological or biochemical pathway through which the intervention is hypothesized to work. This concept serves as a critical bridge between foundational research and clinical efficacy, particularly in complex fields like hormonal health.