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MCT8 Gene

Meaning

The MCT8 Gene, scientifically designated as SLC16A2, encodes the Monocarboxylate Transporter 8, a crucial protein responsible for the active and selective transport of thyroid hormones across the cell membrane, particularly at the highly selective blood-brain barrier and in various peripheral tissues. This transporter is absolutely essential for delivering the metabolically active thyroid hormone, triiodothyronine (T3), to its target cells, which is vital for normal neurological development and systemic energy regulation. Clinically, specific mutations in this gene are associated with a severe X-linked disorder characterized by profound psychomotor retardation.