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MC4R Agonists

Meaning

A class of pharmacological agents that specifically bind to and activate the Melanocortin 4 Receptor (MC4R), a G protein-coupled receptor primarily located in the hypothalamus of the brain. Activation of this critical receptor pathway is a core component of the central melanocortin system, leading to a potent suppression of appetite and an increase in energy expenditure. These agonists are clinically developed for the treatment of specific, severe forms of genetic obesity and weight management.