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Matrikines

Meaning

Matrikines are small, biologically active peptides derived from the proteolytic cleavage of extracellular matrix (ECM) proteins, such as collagen, elastin, and laminin. These fragments function as signaling molecules that communicate the status of the extracellular environment to the cell, playing a crucial role in tissue repair, remodeling, and inflammation. In the context of skin health and aging, they are vital components influencing cellular senescence and dermal integrity.