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Master Signaling

Meaning

Master Signaling describes the central, often hierarchical, regulatory pathways within the endocrine system that exert overarching control over numerous downstream hormonal axes and metabolic functions. The hypothalamic-pituitary axis represents a classic example of this centralized control, dictating systemic endocrine tone across the body. This concept helps organize the complex interplay of hormones into a manageable regulatory architecture for clinical assessment.