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Master Control Switches

Meaning

Master Control Switches are a translational term referring to a small number of key physiological regulatory systems or signaling pathways that exert disproportionately large, systemic influence over multiple interconnected homeostatic processes. In hormonal health, these switches typically include the central circadian clock (SCN), the HPA axis, the insulin signaling pathway, and the mTOR/AMPK metabolic sensing network. Effective clinical intervention requires modulating these few core switches to achieve broad, beneficial downstream effects across all body systems.