Question 1

What is the Meaning of Markov Model?

Accepted Answer

A Markov Model is a specialized mathematical modeling technique employed in health economics and clinical decision analysis to simulate the progression of a patient through a finite set of discrete, mutually exclusive health states over a specified time horizon. This sophisticated analytical tool is essential for calculating the long-term costs and comparative health outcomes, such as quality-adjusted life years (QALYs), associated with competing therapeutic strategies. The model allows researchers to project the cost-effectiveness of various hormonal health interventions across a patient's anticipated lifespan.

Question 2

What is the Origin of Markov Model?

Accepted Answer

The model is named after the Russian mathematician Andrey Markov, who developed the foundational theory of Markov chains in the early 20th century. The application of this probabilistic theory to complex health outcomes and economic evaluation is a later, specialized development within biostatistics and pharmacoeconomics. It is a standard tool for health technology assessment bodies worldwide.

Question 3

What is the Mechanism of Markov Model?

Accepted Answer

The core principle of the Markov Model is the Markov property, which dictates that the probability of transitioning to any future health state depends solely on the patient's current state, independent of the sequence of previous events. By defining the possible health states—such as "disease-free," "on treatment," or "post-complication"—and assigning transition probabilities and associated costs and utilities to each state, the model simulates the clinical pathway. This mechanism provides a quantitative estimate of the lifetime value of a treatment.

Markov Model

Meaning

Origin

Mechanism

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