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MAO-A VNTR

Meaning

MAO-A VNTR refers to a Variable Number Tandem Repeat polymorphism located in the promoter region of the Monoamine Oxidase A gene, a functional genetic variation that significantly influences the rate of gene transcription and subsequent enzyme expression. This polymorphism is critical because the MAO-A enzyme is responsible for the degradation of key neurotransmitters, including dopamine, serotonin, and norepinephrine, thereby modulating an individual’s neurochemical environment. The different repeat lengths are associated with distinct enzyme activity levels.