This refers to a class of synthetic or naturally derived short-chain amino acids used clinically to address specific aspects of male sexual function, including erectile dysfunction, libido, and spermatogenesis. These compounds act as targeted signaling molecules to modulate the neurovascular and endocrine pathways responsible for sexual response. They offer a precise, often localized, therapeutic option.
Origin
The development of these peptides is rooted in the discovery of endogenous neuropeptides, such as melanocortins and growth hormone-releasing peptides, which were found to have secondary effects on sexual arousal and erectile function. This led to the engineering of targeted peptide analogues for clinical sexual health applications.
Mechanism
The primary mechanism involves the modulation of central nervous system pathways and peripheral vascular dynamics. Some peptides, for example, act on melanocortin receptors in the brain to increase sexual desire, while others may promote nitric oxide release in the corpus cavernosum of the penis, leading to vasodilation and improved erectile response. Their function is to enhance the complex neuro-hormonal cascade necessary for healthy sexual performance.
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