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Male Estrogen Metabolism

Meaning

Male estrogen metabolism is the complex set of biochemical processes, primarily occurring in the liver and peripheral tissues, that govern the synthesis, conversion, and eventual clearance of estrogens in the male body. Although testosterone is the dominant androgen, estrogen is produced primarily via the aromatization of androgens, a process essential for bone health, lipid metabolism, and central nervous system function. Proper metabolism is crucial, as imbalances in estrogen levels or unfavorable metabolite ratios can contribute to adverse health outcomes, including prostate concerns and altered body composition.