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Male Estradiol Regulation

Meaning

Male estradiol regulation is the complex physiological process by which the circulating levels of estradiol (E2), the primary estrogen, are maintained within a narrow, essential range in men. Estradiol in males is predominantly synthesized from testosterone via the aromatase enzyme, and it plays crucial roles in bone health, sexual function, and feedback regulation of the Hypothalamic-Pituitary-Gonadal (HPG) axis. Dysregulation, leading to either excessive or deficient estradiol, can manifest as clinical symptoms such as gynecomastia, bone loss, or altered libido. Clinical management often focuses on modulating the aromatase enzyme or addressing underlying metabolic factors like adiposity.