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Macrophage Reprogramming

Meaning

Macrophage Reprogramming is the dynamic process of shifting the functional polarization state of macrophages, a critical type of innate immune cell, from a pro-inflammatory (M1) phenotype to an anti-inflammatory and pro-resolving (M2) phenotype, or the reverse, in response to specific microenvironmental and cytokine cues. This intentional or pathological reprogramming is a critical mechanism in the resolution of chronic inflammation, the process of tissue repair, and the progression or regression of systemic diseases, including complex metabolic and cardiovascular pathology. Therapeutic strategies are often designed to selectively induce this beneficial M2 shift.