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Lysosomal Lipid Turnover

Meaning

Lysosomal lipid turnover is the critical cellular process involving the continuous degradation and recycling of complex lipids, such as sphingolipids and phospholipids, within the acidic environment of the lysosome, the cell’s primary digestive organelle. This process is essential for maintaining cellular homeostasis, clearing damaged or senescent membrane components, and generating reusable lipid building blocks. Impaired lysosomal lipid turnover leads to the accumulation of undigested lipids, a hallmark of various lipid storage disorders and neurodegenerative conditions.