What is the Origin of Luteinizing Hormone Secretion?

The term is rooted in classical endocrinology and reproductive physiology, with Luteinizing Hormone being one of the two gonadotropins identified for its action on the gonads. Its name derives from its role in stimulating the formation of the corpus luteum (luteinization) in the female menstrual cycle. Understanding the dynamics of LH secretion is central to diagnosing and treating conditions related to hypogonadism and infertility.

What is the Mechanism of Luteinizing Hormone Secretion?

LH secretion is tightly regulated by the pulsatile release of Gonadotropin-Releasing Hormone (GnRH) from the hypothalamus; the frequency and amplitude of these GnRH pulses determine the subsequent LH output. The sex steroids themselves, testosterone and estradiol, exert negative feedback on both the hypothalamus and the pituitary, modulating LH release to maintain sex steroid levels within a physiological range. Disruption of this negative feedback loop is a common mechanism in various hormonal dysfunctions.

Luteinizing Hormone Secretion

Meaning

Luteinizing Hormone (LH) Secretion is the pulsatile release of the glycoprotein hormone LH from the anterior pituitary gland, which serves as a primary trophic signal to the gonads in both males and females. In men, LH stimulates the Leydig cells in the testes to synthesize and secrete testosterone, while in women, the LH surge triggers ovulation and supports the corpus luteum’s progesterone production. This precise, rhythmic secretion is fundamental to reproductive function and the maintenance of sex steroid levels.

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Luteinizing Hormone Secretion

Meaning

Origin

Mechanism

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