Question 1

What is the Meaning of Luteinizing Hormone Receptor?

Accepted Answer

The Luteinizing Hormone Receptor (LHR) is a crucial G-protein coupled receptor (GPCR) predominantly situated on the surface of the gonadal cells—specifically the Leydig cells in the testes and the theca and granulosa cells in the ovaries. This receptor serves as the essential molecular target that receives the signal from Luteinizing Hormone (LH) secreted by the pituitary gland. Its activation is the indispensable step that translates a central nervous system signal into the production of sex steroid hormones.

Question 2

What is the Origin of Luteinizing Hormone Receptor?

Accepted Answer

Identified as a key component of the Hypothalamic-Pituitary-Gonadal (HPG) axis, the LHR's discovery was central to mapping the precise feedback loop that controls human reproduction and sexual development. The receptor is named for the hormone it binds, Luteinizing Hormone, which itself is named for its role in promoting the formation of the corpus luteum. Its characterization provided a molecular target for understanding and treating various fertility disorders.

Question 3

What is the Mechanism of Luteinizing Hormone Receptor?

Accepted Answer

Upon the binding of LH to the extracellular domain of the LHR, the receptor undergoes a conformational change, leading to the activation of its coupled intracellular G-protein. This activation stimulates the adenylyl cyclase enzyme, which catalyzes the conversion of ATP to the second messenger cyclic AMP (cAMP). The resulting rapid increase in intracellular cAMP initiates a cascade of phosphorylation events that ultimately drives the key enzymatic steps in steroidogenesis, leading to the synthesis of testosterone, estrogen, and progesterone.

Luteinizing Hormone Receptor

Meaning

Origin

Mechanism

Can Long-Term HCG Use Lead to Leydig Cell Desensitization or Other Endocrine Adaptations?

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