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Luteinizing Hormone Hypersecretion

Meaning

Luteinizing Hormone Hypersecretion describes an endocrine state characterized by the excessive, and often sustained, release of Luteinizing Hormone (LH) from the anterior pituitary gland into the systemic circulation. This condition is a classic hallmark of primary gonadal failure, where the testes or ovaries are unable to produce sufficient sex steroids, leading to a loss of negative feedback inhibition on the pituitary. High LH levels signal the pituitary’s desperate attempt to stimulate a non-responsive gonad. Clinically, this finding is a crucial diagnostic indicator for conditions such as primary hypogonadism, Turner syndrome, or Klinefelter syndrome, reflecting a fundamental breakdown in the Hypothalamic-Pituitary-Gonadal (HPG) axis regulatory loop.