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LRP5

Meaning

LRP5, or Low-density lipoprotein receptor-related protein 5, is a transmembrane receptor protein that functions as a critical co-receptor in the canonical Wnt signaling pathway, a fundamental regulatory cascade in cellular biology. In the context of hormonal and metabolic health, LRP5 is best known for its essential and non-redundant role in regulating bone mass accrual and glucose metabolism. Genetic variations in the LRP5 gene are strongly linked to conditions ranging from high bone density to osteoporosis.