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LRP2

Meaning

LRP2 is the scientific abbreviation for Low-Density Lipoprotein Receptor-Related Protein 2, a very large, multi-functional endocytic receptor protein prominently expressed on the apical surface of various epithelial cells, most notably in the kidney proximal tubules, the thyroid gland, and the brain. In the field of endocrinology, LRP2 plays a crucial, non-redundant role in the cellular reabsorption and subsequent uptake of an exceptionally diverse array of essential ligands, including numerous hormones, critical vitamin-binding proteins, and hormone-binding globulins. Its correct and efficient function is integral to maintaining systemic hormonal and metabolic homeostasis, particularly in the renal conservation of vital circulating molecules.