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Lp(a)

Meaning

Lp(a), or Lipoprotein(a), is a distinct, genetically determined lipoprotein particle in the blood plasma, structurally similar to low-density lipoprotein (LDL) but containing an additional protein called apolipoprotein(a). Elevated concentrations of Lp(a) are a significant, independent, and causal risk factor for atherosclerotic cardiovascular disease, including myocardial infarction and stroke, regardless of conventional lipid panel results. Clinical evaluation of Lp(a) is essential for a comprehensive cardiovascular risk assessment, particularly in individuals with a family history of premature heart disease or those with unexplained elevated LDL-C. It is a critical, often overlooked, marker in preventative cardiology and longevity medicine.