Skip to main content

Low-Level Systemic Inflammation

Meaning

Low-Level Systemic Inflammation, often termed “metaflammation” or “sterile inflammation,” is a chronic, subclinical activation of the innate immune system characterized by persistently elevated, yet mild, circulating levels of pro-inflammatory cytokines and acute-phase reactants, such as C-reactive protein (CRP). This subtle, non-infectious inflammatory state does not typically produce overt acute symptoms but acts as a constant biological stressor, gradually contributing to endothelial dysfunction, insulin resistance, and the progression of age-related chronic diseases. Identifying and mitigating this silent process is a cornerstone of preventative health.