Longevity Science is the interdisciplinary field dedicated to understanding the biological processes of aging and developing targeted interventions to extend human healthspan and lifespan. It integrates genetics, endocrinology, metabolism, and regenerative medicine to identify and modulate the fundamental mechanisms of biological decline. The ultimate goal is to compress morbidity, allowing individuals to live healthier, more vital lives for a longer period.
Origin
This term is a contemporary evolution of gerontology, the traditional study of aging. The addition of “Science” emphasizes the shift toward a rigorous, mechanistic, and intervention-focused approach, driven by advances in molecular biology and systems thinking. The field is propelled by the realization that aging is a modifiable process, not an immutable fate, which can be addressed through systematic biological engineering.
Mechanism
The core mechanism of action in Longevity Science involves targeting the molecular and cellular hallmarks of aging, such as mitochondrial dysfunction, cellular senescence, and loss of proteostasis. Interventions seek to activate endogenous repair systems, including sirtuins and autophagy, and to optimize metabolic pathways to improve cellular energy efficiency and reduce accumulated damage, thereby slowing the rate of biological aging at its roots.
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