What is the Origin of Longevity Substrate Management?

This term is a synthesis of molecular gerontology and clinical biochemistry, driven by the discovery of conserved longevity pathways across species. It shifts the focus from broad dietary recommendations to the specific, measurable biochemical components that regulate cellular senescence and survival. The concept emphasizes the manipulability of the internal biochemical environment.

What is the Mechanism of Longevity Substrate Management?

The core mechanism involves optimizing the cellular balance between catabolism and anabolism, often through the strategic use of precursors or modulators. For instance, increasing NAD+ levels supports sirtuin activity, which enhances DNA repair and mitochondrial function. Management protocols often target nutrient sensing pathways, like mTOR and AMPK, to promote cellular cleanup (autophagy) and metabolic flexibility, thereby extending healthspan.

Longevity Substrate Management ∞ Area

Longevity Substrate Management

Meaning

Longevity Substrate Management is a precision health strategy centered on the deliberate modulation of key metabolic molecules and cellular energy sources that directly influence the aging process. The ‘Substrates’ include molecules like NAD+, Sirtuin activators, and specific amino acids that act as fuel or cofactors for longevity-associated pathways. Effective management aims to maintain youthful levels of these critical compounds to enhance cellular repair and stress resistance.