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Longevity Signaling Rhythms

Meaning

Longevity Signaling Rhythms refer to the temporally organized, cyclical patterns of molecular activity that govern the cellular processes directly linked to biological aging and lifespan extension. These rhythms include the diurnal oscillation of key nutrient-sensing pathways, such as the mTOR and AMPK pathways, and the rhythmic expression of sirtuin genes. Maintaining a robust, high-amplitude rhythm in these signaling cascades is considered critical for optimizing DNA repair, promoting autophagy, and enhancing cellular stress resistance. Dysregulation of these rhythms is a core feature of age-related decline.