Longevity science hormones represent a group of endogenous signaling molecules whose optimal regulation is strongly correlated with extended healthspan and reduced risk of age-related disease. These hormones, which include DHEA, Growth Hormone, Melatonin, and Thyroid hormones, influence fundamental biological processes such as cellular repair, metabolic efficiency, and stress resistance. Maintaining the youthful profile of these hormonal pathways is a key focus in the clinical pursuit of healthy aging.
Origin
This term is a contemporary construct within the emerging field of longevity and anti-aging medicine, drawing upon decades of research in endocrinology and gerontology. It specifically categorizes hormones based on their measurable impact on hallmarks of aging, such as genomic instability, mitochondrial dysfunction, and altered intercellular communication. The concept moves beyond simple hormone replacement to focus on optimizing endocrine function to extend the period of vitality.
Mechanism
Hormones in this category often act as systemic regulators of anabolic and catabolic balance, promoting tissue maintenance and repair. Growth Hormone and its downstream mediator, IGF-1, drive protein synthesis and cellular regeneration, while DHEA serves as a precursor to sex steroids and possesses immunomodulatory properties. Melatonin acts as a potent antioxidant and synchronizes the circadian rhythm, a crucial regulator of nearly all physiological processes, thereby collectively supporting systemic resilience against age-related decline.
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