The rigorous, evidence-based discipline dedicated to identifying, validating, and implementing systematic interventions—spanning pharmaceutical, nutritional, lifestyle, and hormonal domains—designed to extend human healthspan and lifespan. This scientific field relies on clinical trials and molecular biology to develop comprehensive strategies for decelerating the rate of biological aging. It represents the clinical application of geroscience principles.
Origin
The term reflects the formalization of research within geroscience, which posits that aging itself is the single greatest risk factor for chronic disease. Its scientific roots trace back to studies on caloric restriction and the identification of conserved longevity pathways like mTOR and sirtuins. The concept of “protocols” signifies the structured, multi-faceted nature of clinical interventions necessary for measurable anti-aging effects.
Mechanism
The protocols function by targeting the nine hallmarks of aging, including genomic instability, telomere attrition, mitochondrial dysfunction, and altered intercellular communication. Interventions aim to enhance cellular repair mechanisms, optimize metabolic flexibility, and restore youthful hormonal signaling, thereby preserving tissue function and reducing the cumulative damage that drives age-related disease pathology.
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