Longevity Potential is the clinically assessed measure of an individual’s biological capacity to live a long and healthy life, often quantified by various biomarkers of aging and systemic resilience. This potential is a function of both inherited genetic factors and modifiable epigenetic and lifestyle influences that affect the rate of biological aging. Maximizing this potential is the central aim of preventative and anti-aging medicine.
Origin
The term stems directly from the fields of gerontology and biogerontology, which study the mechanisms of aging and the determinants of lifespan. It is a clinical translation of complex biological concepts, such as telomere length, cellular senescence, and epigenetic clocks, into a single, actionable health metric. The concept gained clinical traction with the advent of advanced biological age testing.
Mechanism
Longevity Potential is regulated by key biological pathways, including nutrient sensing pathways like mTOR and AMPK, which govern cellular stress response and repair. Hormonal balance, particularly the optimal function of the growth hormone/IGF-1 axis and thyroid hormones, plays a significant role in maintaining tissue integrity and metabolic rate. Clinical interventions aim to positively modulate these underlying mechanisms to slow the accumulation of cellular damage and enhance intrinsic repair capabilities.
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