This is a therapeutic strategy utilizing specific wavelengths and intensities of light, precisely timed, to modulate the body’s physiological processes with the explicit goal of promoting health span and delaying age-related decline. Phototherapy targets key cellular pathways, including mitochondrial function and circadian rhythm entrainment, to enhance cellular repair and optimize hormonal signaling. This intervention represents a non-pharmacological approach to biological optimization, focusing on light as a powerful metabolic and chronobiological regulator.
Origin
The concept integrates established principles of photomedicine, which uses light for therapeutic purposes, with the emerging science of gerontology and life extension. “Longevity” specifies the ultimate goal of the therapy, while “phototherapy” defines the modality, emphasizing the deliberate use of light to influence biological pathways beyond simple Vitamin D synthesis.
Mechanism
The mechanism involves the absorption of specific light wavelengths by cellular photoreceptors, such as melanopsin in the eyes for circadian regulation, or cytochrome c oxidase in the mitochondria for cellular energy production. Red and near-infrared light, for example, can enhance mitochondrial ATP synthesis and reduce oxidative stress, directly improving cellular function and resilience. Strategically timed blue light, conversely, is used to strengthen the circadian signal and optimize the timing of sleep-wake hormones.
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