Longevity Performance Protocols are structured, integrated programs of interventions—including lifestyle, nutritional, exercise, and sometimes pharmacological strategies—specifically designed to maximize both healthspan and physical/cognitive performance across the lifespan. These protocols are characterized by a systematic, data-driven approach aimed at simultaneously optimizing biological markers of aging and functional capacity. They represent the practical application of geroscience principles.
Origin
This term synthesizes the high-demand rigor of performance training with the long-term, systemic goals of longevity medicine. It arose from the need to translate complex scientific understanding of aging pathways into actionable, measurable clinical plans. The protocols emphasize personalized dosing and timing to achieve maximum adaptive benefit with minimal negative side effects.
Mechanism
The protocols function by strategically applying hormetic stressors, such as intermittent fasting and high-intensity interval training, to activate endogenous repair mechanisms like autophagy and sirtuin signaling. Hormonal modulation is central, ensuring that the body has the necessary anabolic signals—such as optimal testosterone, estrogen, and growth hormone—to recover from these stressors and build functional reserve. This cyclical application of stress and recovery drives systemic resilience and sustained performance.
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