A quantifiable biological or physiological parameter used to assess an individual’s current healthspan, functional capacity, and predicted trajectory toward healthy aging. These metrics move beyond standard disease markers to measure vitality and systemic resilience. Examples include maximal oxygen uptake, grip strength, and specific anti-aging biomarker scores.
Origin
This term is a cornerstone of the burgeoning longevity science and anti-aging medicine movement, emphasizing the measurement of function and vitality over merely the absence of pathology. It merges concepts from exercise physiology and molecular gerontology.
Mechanism
The metrics operate by quantifying the functional output of major organ systems, such as cardiovascular, musculoskeletal, and metabolic health, all of which decline with age. By tracking these performance indicators, clinicians can objectively gauge the effectiveness of longevity interventions, such as optimizing hormone levels or enhancing mitochondrial biogenesis. Improved scores indicate a successful shift toward a more robust, younger biological state.
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