Longevity Pathway Management is a proactive clinical framework centered on optimizing the molecular pathways scientifically associated with extended healthspan and delayed senescence. This includes modulating key cellular processes such as sirtuin activity, AMPK signaling, and mTOR regulation through targeted lifestyle and supplemental interventions. The objective is to enhance cellular resilience and function over time.
Origin
This field is a modern synthesis of molecular gerontology and functional endocrinology, focusing on targets identified in lifespan research across species. Management implies an active, personalized strategy to influence these fundamental biological clocks. It moves the focus from treating disease to promoting inherent cellular maintenance mechanisms.
Mechanism
The mechanism involves activating energy-sensing pathways like AMPK, which promotes mitochondrial biogenesis and cellular cleanup via autophagy, often stimulated by caloric restriction mimetics. Conversely, careful modulation of mTOR signaling prevents excessive anabolic signaling that can accelerate aging phenotypes. By influencing these master regulators, we aim to preserve tissue integrity.
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