The specialized field of study focused on the neural and molecular mechanisms that govern brain aging, cognitive reserve, and the resilience of the central nervous system throughout the lifespan. It integrates endocrinology, genetics, and neurobiology to understand how systemic factors, including hormonal milieu and metabolic health, influence synaptic plasticity and neuroprotection. The ultimate goal is to identify and implement targeted interventions that preserve and enhance neurological function well into advanced age.
Origin
This is an emerging, interdisciplinary domain combining traditional neuroscience with the modern scientific pursuit of longevity. It reflects the growing recognition that brain health is a primary determinant of healthspan and that the brain’s vulnerability to age-related decline is heavily modulated by systemic factors.
Mechanism
Longevity neuroscience investigates mechanisms such as telomere maintenance in neural cells, the efficiency of cerebral mitochondrial function, and the role of neurotrophic factors like BDNF, which is often influenced by exercise and hormonal status. It examines how hormones, including estrogen and testosterone, exert neuroprotective effects by modulating oxidative stress and promoting neuronal repair. Strategies derived from this field aim to enhance these intrinsic mechanisms, supporting the brain’s structural integrity and functional connectivity against age-related decline.
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