The strategic administration or activation of specific endogenous or exogenous compounds that have been scientifically demonstrated to influence the fundamental molecular pathways associated with biological aging. This application is centered on improving healthspan by targeting mechanisms like DNA repair, epigenetic regulation, or senolytic activity. It represents an evidence-based attempt to influence the aging trajectory at a foundational level.
Origin
This terminology originates from the convergence of molecular biology and gerontology, where specific molecules (e.g., NAD+ precursors, sirtuin activators) are identified as key modulators of cellular lifespan. Application signifies their controlled use in human wellness protocols.
Mechanism
The mechanism of action varies depending on the molecule, but often involves enhancing cellular resilience. For example, supporting NAD+ levels directly fuels sirtuins, which regulate mitochondrial health and DNA repair mechanisms. Other applications might involve promoting autophagy to clear damaged organelles, thereby reducing cellular burden and systemic inflammation associated with senescence.
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