The optimal ratio and quality of macronutrients—specifically carbohydrates, fats, and proteins—along with their associated micronutrients, selected to support cellular repair, genetic stability, and metabolic flexibility over the lifespan. This composition is designed to minimize pro-aging signals like chronic hyperglycemia and maximize protective signals like autophagy. It is a precision nutritional approach to extending healthspan.
Origin
This term is a conceptual blend of “Longevity” research, focusing on the biological mechanisms of aging, and “Fuel Composition,” a term from nutritional science. It represents a precision nutrition approach to metabolic health. The term reflects the growing clinical focus on nutrition as a modulator of the aging process.
Mechanism
The composition favors nutrient sources that promote mitochondrial efficiency and reduce the generation of reactive oxygen species. This often involves prioritizing high-quality fats for structural integrity and signaling, balanced protein intake for amino acid signaling, and complex carbohydrates for sustained, low-glycemic energy release. The overall goal is to maintain a favorable metabolic balance that supports DNA repair and cellular resilience, directly influencing cellular lifespan.
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