Longevity Factors are the measurable, biological, and environmental variables that have a statistically significant correlation with an extended and healthy human lifespan, often referred to as healthspan. These factors encompass a range of domains, including specific genetic polymorphisms, optimized hormonal profiles, favorable metabolic markers, and protective lifestyle behaviors. Clinically, identifying and optimizing these factors serves as the foundation for a proactive, preventative health strategy.
Origin
This term arises from the extensive epidemiological and genetic research in gerontology, where scientists study centenarians and long-lived populations to isolate common biological and environmental traits. The concept gained clinical relevance through functional and preventative medicine, which emphasizes assessing individual risk based on a comprehensive profile of these factors. It moves beyond simple disease risk to focus on the active promotion of long-term biological resilience.
Mechanism
Longevity Factors operate by reinforcing the body’s intrinsic mechanisms for repair, adaptation, and survival. Biologically, this includes maintaining optimal levels of growth and sex hormones, which support tissue integrity and metabolic function, alongside low levels of inflammatory markers. Lifestyle factors, such as regular physical activity and nutrient density, act as powerful modulators of gene expression and cellular signaling pathways, thereby directly influencing the rate of biological aging and maintaining homeostatic hormonal control.
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