A set of deliberate, evidence-informed nutritional frameworks and behavioral tactics employed to influence the body’s fundamental aging pathways, with the primary goal of extending healthspan and reducing the incidence of chronic metabolic and degenerative diseases. These strategies move beyond simple calorie counting to focus on nutrient timing, quality, and the strategic induction of cellular stress responses.
Origin
The foundation of these strategies lies in the study of centenarian populations and the molecular biology of aging, integrating findings from caloric restriction, intermittent fasting, and macronutrient manipulation research. The term emphasizes the strategic, planned nature of these dietary interventions.
Mechanism
Effective longevity strategies leverage hormesis by utilizing periods of fasting or nutrient deprivation to upregulate protective cellular mechanisms, including DNA repair and mitochondrial biogenesis, often mediated by the AMPK pathway. By modulating the insulin/IGF-1 signaling axis, these diets reduce the signaling for unchecked growth, thereby shifting the metabolic profile towards maintenance and resilience, which is a hallmark of slower biological aging.
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