An advanced, interdisciplinary field dedicated to thoroughly understanding the complex neurobiological, hormonal, and specific lifestyle factors that collectively support sustained, high-level cognitive function and minimize the rate of age-related decline across the entire human lifespan. This science focuses intently on maintaining high-fidelity brain performance and robust neuroplasticity well into advanced chronological age. The clinical application integrates endocrinology, advanced genetics, and behavioral interventions to comprehensively optimize the cognitive healthspan.
Origin
This emerging field synthesizes key insights from gerontology, cognitive neuroscience, and experimental psychology, fundamentally shifting the clinical focus from merely treating age-related cognitive pathology to proactively promoting neuroprotection and plasticity. The central philosophical driver is the pursuit of extending the “healthspan,” rather rather than just focusing on life extension alone. This approach rigorously acknowledges the profound, inseparable connection between systemic biological health and long-term brain vitality.
Mechanism
The core mechanism of intervention involves actively managing key biological processes that accelerate brain aging, such as chronic systemic inflammation, detrimental oxidative stress, and profound metabolic dysregulation. Circulating hormones like thyroid, estrogen, and testosterone act as essential modulators of neuronal survival, dendritic structure, and synaptic function. Effective interventions often target the enhancement of endogenous neurotrophic factors and the precise optimization of mitochondrial function to meet the high, sustained energy demands of the brain.
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