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Longevity Circuitry

Meaning

Longevity Circuitry is a conceptual, comprehensive framework referring to the interconnected network of molecular pathways, essential endocrine axes, and fundamental cellular mechanisms that collectively govern the rate of biological aging and ultimately determine an individual’s healthspan. It encompasses fundamental regulatory systems such as the sirtuins, mTOR, AMPK, and the critical insulin/IGF-1 signaling cascade. Optimizing the function of this intricate circuitry is the primary clinical goal of interventions aimed at extending vitality and significantly delaying age-related functional decline.