This refers to the specific, quantifiable biochemical or hormonal state that must be achieved and maintained within the body to maximize healthspan and extend lifespan. It is not merely the absence of disease but the presence of optimal concentrations and ratios of key signaling molecules that promote cellular repair, resilience, and resistance to senescence. Identifying these prerequisites guides precision longevity protocols. This chemical foundation supports sustained high-level function.
Origin
This concept arises from the molecular and genetic research into aging, particularly the study of centenarians and model organisms where specific biochemical pathways are linked to extended life. The term emphasizes the necessity of a particular chemical environment, moving beyond simple association to a requirement for sustained physiological youth. It is a core tenet of modern bio-gerontology and anti-aging research.
Mechanism
Prerequisite chemicals often include optimal levels of specific hormones, such as DHEA-S and growth hormone, which decline with age, or the balanced activity of metabolic sensors like AMPK. The mechanism involves these molecules modulating fundamental longevity pathways, including DNA repair, proteostasis, and mitochondrial biogenesis. Maintaining this optimal chemical state acts as a systemic signal that favors repair and maintenance over decline and degradation.
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