A comprehensive assessment methodology involving the serial measurement and analysis of specific biological indicators associated with aging and healthspan trajectory, extending beyond standard clinical chemistry panels. This profiling aims to capture dynamic biological age rather than chronological age, providing objective data for personalized intervention planning. It seeks to quantify resilience at the molecular level.
Origin
This practice is a direct descendant of geroscience and advanced clinical diagnostics, incorporating epigenetic clocks, telomere length analysis, and detailed assessment of hormonal panels related to senescence.
Mechanism
Profiling operates by establishing a baseline for key longevity regulators, such as NAD+ precursors, sirtuin activity proxies, and the functional status of sex hormone and thyroid axes. By tracking changes in these specific biomarkers over time, clinicians can objectively measure the efficacy of implemented lifestyle or therapeutic modifications. This iterative feedback loop allows for continuous refinement of strategies targeting cellular maintenance and repair pathways.
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