Longevity Biomarker Correction is the targeted clinical strategy of normalizing or optimizing measurable biological indicators that correlate strongly with extended healthspan and lifespan. These biomarkers, which include metrics like telomere length, epigenetic age (e.g., Hannum or Horvath clocks), mitochondrial function indices, and specific inflammatory markers (e.g., hs-CRP), serve as objective proxies for the body’s true biological age and systemic health. Correction involves precision interventions designed to move these indicators from a suboptimal, age-accelerated state toward a youthful, resilient baseline.
Origin
This phrase is a construct of modern gerontology and precision medicine. “Longevity Biomarker” refers to the measurable biological characteristics identified through research that predict future health and lifespan. “Correction” is a term from clinical practice, denoting the therapeutic act of adjusting a pathological or suboptimal reading back toward a desired, healthy range. It signifies an active, rather than passive, approach to aging.
Mechanism
Correction strategies target the underlying hallmarks of aging. For example, interventions may aim to reduce cellular senescence by clearing senescent cells, thereby correcting inflammatory biomarkers. They might also involve nutritional or pharmaceutical agents that enhance telomerase activity or promote DNA repair mechanisms to stabilize telomere length and reduce genetic instability. The mechanism is a multi-faceted attack on the core drivers of biological aging, utilizing personalized data to validate the efficacy of each intervention in improving the prognostic health indicators.
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