The Longevity Biological Foundation encompasses the core physiological and molecular processes that underpin healthy aging and the extension of healthspan. This foundation includes optimal mitochondrial function, robust cellular repair mechanisms, efficient genetic expression, and balanced hormonal signaling. Maintaining the integrity of these foundational elements is essential for delaying age-related decline and promoting sustained vitality.
Origin
This concept is a synthesis of gerontology, molecular biology, and endocrinology, aiming to define the fundamental biological pillars of a long and healthy life. The term moves beyond simple lifespan extension to focus on the quality of health—the ‘healthspan.’ It represents a shift from disease management to proactive biological optimization.
Mechanism
A strong biological foundation is sustained by optimizing metabolic pathways, such as mTOR and AMPK signaling, which regulate cellular growth and repair in response to nutrient status. It also requires the maintenance of endocrine resilience, ensuring that key hormones like DHEA, growth hormone, and thyroid hormone remain within functional ranges. This concerted mechanism protects against cellular senescence and promotes tissue regeneration.
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